Researcher

Researcher Job Description in Cancer Biology

School:Department of Internal Medicine, The Ohio State University.

Description:We are seeking highly motivated and enthusiastic Ph.D. or MD scientists to join our group as postdoctoral research fellows.

We are now accepting applications for a Researcher position in the laboratory of Dr. Triparna Sen at the Department of Internal Medicine, Division of Medical Oncology, at The Ohio State University.

Dr. Sen is a Professor in the Department of Internal Medicine, at The Ohio State University. The Sen lab aims to achieve a systematic and comprehensive understanding of the mechanisms of initiation, progression, and therapeutic resistance in lung cancer. The lab has established the use of multiple high-throughput screening technologies, genomics, proteomics, metabolomics, clinical samples, and animal models to accomplish these goals. The results will lead to the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.

Position Summary:

The Researcher will be a core technical member of the lab, supporting all aspects of translational research with a focus on:

• CRISPR screening platforms
• Drug dosing studies in both in vitro and in vivo settings
• Clinical sample processing, including the development of patient-derived xenograft (PDX) models

The successful candidate will work closely with postdoctoral fellows and other technical staff and play an integral role in executing experiments, maintaining research infrastructure, and supporting the broader goals of the lab.

Responsibilities:

• Design and execute CRISPR-Cas9-based genetic screens in lung cancer cell models
• Culture and manipulate human lung cancer cell lines and organoids, including transfections and viral transductions
• Perform drug sensitivity assays in vitro and conduct dosing studies in mouse xenograft models
• Establish and maintain PDX and CDX models using immunocompromised mouse strains (NSG, NRG, athymic nude)
• Process human lung tissue specimens for downstream molecular and cellular analyses, including:
  • RNA/protein extraction
  • Flow cytometry and cell sorting
  • Single-cell suspensions for sequencing or culture
• Operate lab equipment including GentleMACS Cell Dissociator, flow cytometers, biosafety cabinets, and centrifuges
• Coordinate mouse studies: monitor health, measure tumor burden, maintain accurate animal records in compliance with IACUC protocols
• Prepare experimental reagents, solutions, and maintain lab stocks
• Organize and update biobank/sample databases and maintain meticulous experimental records in ELN or lab notebooks
• Assist in procurement of lab reagents and equipment; coordinate with administrative staff for ordering and service contracts

Required Qualifications:

• Master of Science Degree in Life Sciences or a related field.
• 5 years of relevant lab experience preferably (but not limited to) in cancer biology.
• Proficiency in cell culture and standard molecular biology techniques.
• Experience handling mice, including tumor implantation and drug administration is a requirement for this position.
• Excellent interpersonal skills, problem-solving flexibility, and adaptability able to interface with lab staff.
• Adept at planning and prioritizing work to meet commitments with a keen eye for detail.
• Action-oriented and eager to take on new opportunities and tough challenges with a sense of urgency, high energy, and enthusiasm.

Application Requirements: In addition to workday application requirements.

Please upload as a single PDF file by September 15, 2025:

• Cover letter (maximum 2 pages) indicating research background, interest in the position, and expected start date
• Curriculum Vitae (CV)
• Reprints or PDFs of up to two relevant publications (if available)
• Names and contact information of three professional references

Principal Investigator:

Dr. Triparna Sen

Professor, Department of Internal Medicine,

Associate Director of Research, Division of Medical Oncology

Director, Preclinical Therapeutics Platform,

The Ohio State University,

The Arthur G. James Comprehensive Cancer Center

508 Biomedical Research Tower

460 W 12Th Ave , Columbus, OH 43210

Function: Research and Scholarship

Sub Function: Research

Career Band: Individual Contributor – Specialized

Career Level: S3

The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nations largest and most comprehensive public universities and a top employer in Ohio.

As one of only 54 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies providing tomorrows standard of care today. A Cancer-Free World Begins Here.

The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.